7,8-Dihydroxyflavone Powder

7,8-Dihydroxyflavone Powder – High-Purity TrkB Agonist for Advanced Neuroprotection & Cognitive Enhancement

Xi'an Le-Nutra Ingredients Inc. is a professional manufacturer of pharmaceutical grade 7,8-Dihydroxyflavone Powder with HPLC testing ≥98.0% purity. We are a world-leading supplier of this high-bioavailability TrkB receptor activator, supplying nutraceutical manufacturers, research institutions and functional food developers with our 60,000㎡ GMP-compliant production facility and 3,000-ton annual capacity across 6 multifunctional production lines, ensuring a stable supply. Competitive price (straight from our factory) Consistency from batch to batch All documents including COA, TDS and MSDS compliance with FDA regulations to give you trust

What Is 7,8-Dihydroxyflavone Powder?

7,8-Dihydroxyflavone (CAS: 38183-03-8) is a synthetic refined flavone and a selective Tropomyosin receptor kinase B (TrkB) agonist. Unlike endogenous Brain-Derived Neurotrophic Factor (BDNF), which has low blood-brain barrier penetration and quick degradation, this small-molecule alternative readily penetrates the BBB and has prolonged half-life.

This chemical activates downstream signalling pathways that are essential for neuronal survival, synaptic plasticity and cognitive function. It has molecular weight 254.24g/mol and melting point 253-255°C and shows better thermal stability than peptide based alternatives.

Its application solves fundamental industry problems in neuro-regenerative formulations with oral bioavailability above 40% and no sophisticated delivery systems. The standards are research-grade and suitable for use in clinical studies and commercial product development.​​​​​​​

Technical Specifications & Quality Parameters

Core Functional Benefits for Formulation Development

Our 7,8-Dihydroxyflavone Powder activates TrkB receptors to initiate multiple neuroprotective cascades. It enhances hippocampal synaptic plasticity, improving memory consolidation and spatial learning performance in cognitive health formulations.

The substance has significant anti-neuroinflammatory activity through the inhibition of microglial activation and the downregulation of proinflammatory cytokine expression. It is suitable for age-related cognitive decline supplements and for neurodegenerative research applications.

It acts as an antioxidant to protect neuronal cells from apoptosis generated by oxidative stress. It also acts as an anxiolytic by modulating the hypothalamic-pituitary-adrenal axis to enhance mood equilibrium. The possible metabolic health benefits are because of TrkB activation in muscle tissue, which could increase energy expenditure.

This chemical is being used in clinical research procedures for investigations on Alzheimer's, Parkinson's and ALS diseases where traditional BDNF medications do not work due to delivery issues.

Manufacturing Excellence & Production Capabilities

Our 14+ years of experience in extracting and refining synthesis from natural ingredients guarantee uniform quality for every batch. The 60,000㎡ production facility is GMP, ISO and FDA certified and equipped with specialised QC facilities for real-time HPLC analysis.

Six multi-purpose production lines allow adjustable batch sizes from research-grade kilos to commercial-scale tonnes. Using advanced purification techniques, residual solvents are maintained within ICH guideline limits and crystalline structure integrity is assured.

98% on-time delivery and 30+ days of safety stock to serve urgent R&D initiatives and scheduled bulk orders. We provide end-to-end supply chain integration from raw material procurement to final packaging for traceability and regulatory compliance.

Partnerships with third party testing companies confirm levels of heavy metals, microbiological safety and solvent residues to fulfil international food, pharmaceutical and nutraceutical requirements for worldwide markets.

Industry Applications & Formulation Solutions

Cognitive Enhancement Supplements: Integrate into nootropic capsules or tablets at 50-100mg daily dosages for memory support and focus improvement. Compatible with phosphatidylserine and Bacopa monnieri in synergistic blends.

Neuroprotection Research: Supplied as research-grade reagent for neurodegenerative disease studies requiring high purity and documentation for ethical approval. Suitable for in vitro and in vivo protocol development.

Anti-Aging Functional Products: Formulated into oral beauty supplements targeting age-related cognitive decline, often combined with collagen peptides and astaxanthin for comprehensive cellular protection.

Weight Management Formulas: Emerging applications leverage TrkB-mediated metabolic effects in thermogenic blends, particularly for populations seeking exercise-mimetic benefits.​​​​​​​

Comprehensive OEM/ODM Customization Services

We offer complete range of customisation from formula optimisation to private labelling. Our R&D team will customise purity parameters, particle size distribution and carrier systems to match your product positioning.

Bulk orders are available in 25kg fibre drums with double layer food grade polyethylene bags and we can supply small volume custom packaging for retail products. We support multi-language labelling with regulatory acceptable ingredient disclosures.

Delivery terms adapt to your logistics preferences: EXW, FOB, CFR, CIF, DAP, or DDP. Payment Terms: 100% T/T, Alibaba Trade Assurance and Western Union for global transaction safety.

Technical consultation: stability testing, formulation compatibility analysis, regulatory documentation creation for target markets (EU, USA, APAC areas).

FAQ

Q: What formulation types work best with this ingredient?

A: It processes efficiently into brain health memory capsules, anti-anxiety cognitive support supplements, neuroprotection research trial reagents, and anti-aging functional oral products. Lipid-based delivery systems enhance absorption for low-dose applications.

Q: What are the key physical and chemical characteristics?

A: The pale yellow odorless crystalline powder dissolves readily in alcohol solvents while remaining stable under sealed low-light storage. Its low moisture absorption rate prevents raw material agglomeration during handling and manufacturing.

Q: How do you ensure quality compliance?

A: Every batch undergoes full HPLC testing with compliance to ISO, FDA, and Kosher global standards. All heavy metal and microbial indicators meet international food safety requirements, supported by third-party verification available upon request.

Partner With a Reliable 7,8-Dihydroxyflavone Powder Manufacturer

Contact our technical team at enquiry@lenutra.com for 7,8-Dihydroxyflavone Powder samples, specifications, and custom solution design tailored to your market requirements.