Calcium Alpha-Ketoglutarate Powder
Description
Calcium Alpha-Ketoglutarate Powder – High-Purity Food Grade Supplement Ingredient for Sports Nutrition and Bone Health Solutions
Xi'an Le-Nutra Ingredients Inc. is a professional manufacturer and supplier of pharmaceutical-grade Calcium Alpha-Ketoglutarate Powder, 99.0% assay purity, produced in our 60,000㎡ GMP plant with 3,000-ton annual capacity. Our Ca-AKG powder provides a bioavailable calcium source and alpha-ketoglutarate, a key intermediary in the Krebs cycle that supports energy metabolism at the cellular level as well as bone density and recovery after exercise. With more than 14 years of experience in the metabolic ingredient production and continuous stock inventories, we have a 98% on time delivery record for worldwide nutraceutical producers. All batches are tested via HPLC and titration methods to guarantee they meet FDA, ISO, and Kosher requirements, making it perfect for use in sports nutrition capsules, bone health formulas and anti-aging supplements.

What Makes Our Calcium α-Ketoglutarate Different?
Unlike free-form alpha-ketoglutaric acid which degrades rapidly in an acidic environment, our calcium-buffered formulation eliminates the stability problem for dietary supplement makers. Its crystalline monohydrate structure maintains a neutral pH to prevent gastrointestinal upset while retaining the molecule's function as a nitrogen scavenger and ammonia detoxifier.
Your formulation has the great advantage of dual-action support: the calcium component provides skeletal integrity since it contains 18-20% elemental calcium and the AKG portion powers the tricarboxylic acid cycle to generate ATP energy. The synergistic use of this combination of our powder is most suited to target cellular energy depletion in ageing populations and metabolic waste accumulation in athletes.
We produce our synthetic product with 4.0-6.0% moisture content, which prevents clumping during encapsulation. The white crystalline powder flows readily through high-speed tableting equipment, decreasing manufacturing downtime and boosting batch consistency on your production lines.
Technical Specifications and Quality Parameters
| Item | Specification |
|---|---|
| Product Name | Calcium α-ketoglutarate monohydrate Powder |
| CAS No. | 402726-78-7 |
| Source | Food-grade synthetic raw material |
| Active Ingredient | Calcium α-ketoglutarate monohydrate |
| Appearance | White free-flowing crystalline powder |
| Assay | ≥99.0% (Titration & HPLC) |
| Solubility | Slightly soluble in water, insoluble in ethanol |
| Loss on Drying | 4.0%–6.0% (monohydrate standard) |
| Total Ash | ≤0.5% |
| Heavy Metals | Pb <10 ppm, As <2 ppm, Cd <1 ppm, Hg <0.1 ppm |
| Microbial Limits | TPC ≤1000 CFU/g; Yeast & Mold ≤100 CFU/g; E. coli & Salmonella negative |
| Storage & Shelf Life | 24 months in cool, dry, dark, airtight conditions |
Core Health Benefits for Product Formulation
Increased Calcium Bioavailability
Calcium supplements have a competitive edge with our superior absorption chelated calcium vs carbonate or citrate competitors for bone health. The carrier molecule alpha-ketoglutarate increases absorption in the intestine and incorporation into the bone matrix.
Optimise Exercise Recovery
Our powder is used in sports nutrition to help alleviate post-workout weariness by promoting glutamine synthesis. The nitrogen balance regulatory mechanism enhances muscle tissue regeneration and removes ammonia byproducts after severe physical activity.
Metabolic Energy Support
The Krebs cycle intermediate, AKG in this supplement, refills your cellular energy pathways. This deals with the ATP depletion experienced by consumers during calorie restriction or mitochondrial ageing.
Protection of Renal Function
The kidney-care formulations' ammonia detoxification characteristics promote healthy nitrogen metabolism in individuals with increased urea levels or protein-rich diets.
Application Scenarios Across Industries
Your development team can formulate our Calcium Alpha-Ketoglutarate Powder into multiple product categories. Bone health tablets combine it with vitamin D3 and magnesium for osteoporosis prevention. Sports nutrition capsules blend it with BCAAs for endurance athletes. Kidney-care functional foods incorporate it into low-protein snack bars. Anti-aging supplement brands use it in longevity stacks targeting cellular senescence.
The powder's neutral pH and low hygroscopicity allow direct compression or encapsulation without additional excipients. This simplifies your supply chain and reduces formulation costs while maintaining stability through 24-month shelf life.
Manufacturing Excellence and Compliance Assurance
Our six multipurpose production lines are working strictly according to the GMP regulations with real time quality monitoring. Each production batch is subjected to acid-base titration for calcium concentration and HPLC analysis for alpha-ketoglutarate purity. We hold more than 30 days of safety stock to protect against supply chain interruptions.
With every shipment you will get third-party testing results which include COA, TDS, MSDS and MOA documentation. Our quality system complies with FDA GRAS guidelines, ISO 9001 production practices and Kosher certification to open doors in worldwide markets.
Heavy metal screening guarantees lead levels of less than 10 ppm and arsenic less than 2 ppm, exceeding the standards of California Prop 65. Microbial testing of all batch releases confirmed no presence of E. coli and Salmonella.

Flexible OEM/ODM Customization Services
We tailor specs to your end application. Pharmaceutical grade items are available in higher purity grades (99.5%+). Customised particle size distribution improves flow properties for your encapsulation equipment. In addition to the basic 25 kilogram fibre drum, we offer private label services such as label design, regulatory compliance review and packaging customisation.
Your R&D team has technical support through the product development. Our scientists can help you improve solubility, conduct stability testing under expedited settings and assess compatibility with additional active ingredients in your formulations.
Packaging and Global Delivery Solutions
Standard packing is 25 kg fibre drums with double layer food grade polyethylene liners to avoid moisture infiltration. We are able to do custom packaging from 1 kilogram foil bags for sampling up to bulk totes for big volume manufacturing.
If you need it urgently, we send in-stock orders within 3-7 working days by sea freight, air cargo or express courier. We provide EXW, FOB, CFR, CIF, DAP, DDP delivery terms with proper documents for custom clearance. Payment flexibility: 100% T/T, Alibaba Trade Assurance, Western Union.
Our logistics partners, who maintain temperature-controlled transportation for summer shipments to tropical countries, ensure your powder reaches in perfect crystalline state.
FAQ
Q: What makes calcium-bound AKG more stable than free acid form?
A: The calcium salt neutralizes the carboxylic acid groups, preventing thermal degradation and moisture-induced hydrolysis that compromises pure alpha-ketoglutaric acid during storage.
Q: Can this ingredient be used in vegan formulations?
A: Yes. Our synthetic production process uses no animal-derived materials, making it suitable for vegan and vegetarian supplement lines when certified with appropriate documentation.
Q: What is the recommended dosage range for finished products?
A: Clinical studies typically use 1-3 grams daily. Your formulation should account for the 80-82% AKG content after calcium adjustment, balancing efficacy with tablet size and consumer compliance.
Q: How does your pricing compare to imported European suppliers?
A: Direct factory supply eliminates distributor markups, offering 20-35% cost savings while maintaining equivalent purity standards. Volume discounts apply for orders exceeding 500 kg.
Q: Do you provide samples for formulation testing?
A: We supply 100-500 gram samples with full analytical documentation. Sample requests receive priority processing with 48-hour dispatch for international courier delivery.

Partner With a Trusted Ingredient Supplier
Contact our technical team at enquiry@lenutra.com to discuss your Calcium Alpha-Ketoglutarate Powder requirements and request samples today.
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