Piperlongumine Powder

Premium Piperlongumine Powder – High-Purity Senolytic Active Ingredient for Next-Generation Anti-Aging Supplements

Xi'an Le-Nutra Ingredients Inc. offers pharmaceutical-grade Piperlongumine Powder with HPLC tested purity ≥98.0% extracted from natural plant sources and designed for advanced longevity nutraceuticals. Supported by our 60,000㎡ GMP-certified production base and 3,000-ton annual production capacity, this off-white to light yellow crystalline powder (CAS 20069-09-4) achieves targeted clearance of senescent cells through dual anti-inflammatory and antioxidant processes. Our production controls of total impurities (≤1.0%), loss on drying (≤1.0%) and heavy metals (≤10ppm) are stringent, guaranteeing consistent bioactivity for cellular health formulations. We offer consistent supply solutions for worldwide dietary supplement manufacturers and research institutions with 14+ years of extraction competence, 98% on-time delivery and 30+ days safety stock.

What is Piperlongumine Powder?

It is a crystalline alkaloid of the long pepper plant (Piper longum). The product is standardised to medicinal purity levels using precision extraction and purification procedures. The molecule differs from traditional antioxidants in that it works by selectively targeting senescent cells, the old, defective cells that amass in tissues and generate chronic inflammation.

In terms of molecular properties, the powder exhibits a well defined melting temperature range (123-127 °C) and a negligible residual solvent content (ethanol ≤0.05%) which makes it appropriate for heat sensitive encapsulation operations. It is lipophilic and hence can be easily incorporated in an oil based delivery system and is stable under controlled storage conditions.

This chemical solves the formulation challenge of adding senolytic drugs for B2B customers without the instability issues associated with liquid extracts. The crystalline structure guarantees perfect dosage accuracy and a shelf life of 24 months when maintained properly.

Technical Specifications and Quality Parameters

Our analytical protocols include NMR and LC-MS identification to confirm molecular structure, ensuring batch-to-batch consistency for regulatory compliance and clinical-grade applications.

Five Core Functional Advantages for Your Formulations

Targeted Clearance of Senescent Cells

The powder has selective cytotoxicity to ageing cells, without injuring normal tissue. This technique tackles the fundamental cause of cellular ageing, not just neutralising free radicals. For longevity supplement makers, it means differentiated product claims supported by rising senolytic science.

Dual Anti-Inflammatory and Antioxidant Effect

The substance provides multi-target protection by regulating both oxidative stress pathways and inflammatory signalling cascades. This dual action facilitates formulation development, requiring less complex stacking of ingredients and boosting efficacy profiles.

Natural Plant-Derived Origin with High Bioavailability

The substance, which comes from traditional botanicals, fits clean-label norms and offers better absorption than synthetic versions. Its botanical source lends itself to marketing stories about botanical wellness without sacrificing pharmaceutical-grade quality standards.

Physical and Chemical Properties Stability

The crystalline structure does not degrade under normal manufacturing circumstances. This powder, unlike heat sensitive polyphenols or volatile oils, can survive typical tablet pressing, capsule filling and powder blending processes without loss of action. Stability is maintained for 24 months shelf life under cool, dry, and light-protected storage conditions.

Wide Application Scope of Dietary Supplement

The constituent is compatible with hard capsules, softgels, tablets and powder blends and fits seamlessly into existing manufacturing procedures. Works synergistically with resveratrol, curcumin and collagen peptides in anti-ageing formulations without solubility conflicts or incompatibility concerns.

Application Scenarios for Product Development

This excellent raw material can be used in a wide range of product categories:

Anti-Aging Longevity Capsules – Formulate high-end supplements targeting healthspan extension and cellular rejuvenation. The crystalline powder enables accurate dosage in milligrams for standardised daily serving amounts.

Cellular Health Support Tablets – Combine with NAD+ precursors or mitochondrial cofactors for complete cellular vitality formulae. The stability of the powder maintains potency consistency during the shelf life of the product.

Anti-Inflammatory Functional Food Blends – For protein powders, smoothie mixes or nutritional bars for the fitness and recuperation markets. The off-white colour and neutral flavour mean it won’t affect the flavour or appearance much.

Senolytic Research Nutraceutical Raw Materials – Supply raw materials to research institutions and biotech companies for the development of next-generation longevity therapies. Pharmaceutical-grade purity and complete documentation to satisfy your preclinical and clinical study needs.

Formulation Compatibility and Storage Stability

Our product has good lipophilic solubility and can be used in most processes for oral formulations. It is easily used with other active substances such as resveratrol, curcumin and collagen peptides and does not have precipitation or separation problems.

The substance has stable physical and chemical properties under normal temperature and storage in the dark. Independent stability studies demonstrate that when stored correctly, there is no appreciable degradation or loss of action. The Piperlongumine Powder is an off-white to light yellow powder with a crystalline structure throughout the 24-month shelf life.

Store below 25°C and relative humidity below 60% for optimum stability. The fibre drums are lined with double layer polyethylene bags of food grade, which are good barriers to moisture and oxygen. Avoid the storing and transportation in an environment of direct sunshine and excessive temperature.

Production Capacity and Supply Chain Reliability

We have a 60,000㎡ plant with six multipurpose production lines and modern extraction and purification systems. This infrastructure can handle conventional specifications and unique purity needs and process raw materials through controlled stages of extraction, crystallisation, drying and micronization.

We have buffer inventory to cover urgent requests and seasonal demand variability with 3,000 tonnes of annual capacity and over 30 days of safety stock. Our strong raw material relations with certified organic farms assure stable quality from harvest to finished powder manufacture.

Inventory items ship within 3-5 days of order confirmation. 10-12 days for production and quality verification, bulk or high purity bespoke specs. We have experienced goods forwarders to organise global logistics to make overseas procurement easy. We can offer EXW, FOB, CFR, CIF, DAP and DDP delivery terms.​​​​​​​

Quality Control and Compliance Documentation

Every production run is fully tested in our ISO lab. Our quality control procedures include HPLC purity testing, ICP-MS heavy metals screening, GC residual solvents analysis and microbial contamination evaluation according to pharmacopeial standards.

We provide full paperwork to satisfy your regulatory requirements like FDA registration, ISO certifications, Certificate of Analysis (COA), Technical Data Sheet (TDS), Material Safety Data Sheet (MSDS), Method of Analysis (MOA), NMR/LC-MS identification reports. Third-party testing can be arranged upon request.

Each product lot is traceable back through the full batch to the raw material sources, the processing settings and the quality test findings. This documentation chain meets audit requirements for dietary supplement GMP compliance in the North American, European and Asia-Pacific markets.

Packaging and Storage Guidelines

Standard commercial packaging is 25kg fibre drums with double layer food grade polyethylene bags to prevent moisture penetration and contamination. This setup ensures product integrity during sea freight, air freight and storage in warehouses.

Keep in cool, dry places, away from direct sunlight and heat sources. Ambient temperature should be below 25°C and relative humidity below 60%. Close inner bags tightly after opening. To ensure best quality, use contents within three months of opening.

Custom packaging is available to meet regional requirements or downstream processing needs. Talk to our technical staff about packaging alternatives that can fit into your production flow.

FAQ

Q: What distinguishes high-purity piperlongumine from standard extracts?

A: Pharmaceutical-grade powder at ≥98.0% purity removes interfering compounds that may cause batch-to-batch variability. This standardization ensures predictable bioactivity and simplifies regulatory submissions compared to crude extracts containing multiple alkaloids.

Q: Can the powder be used in heat-processed formulations?

A: The melting point range of 123-127°C indicates thermal stability suitable for standard tablet compression and capsule filling operations. However, prolonged exposure above 150°C should be avoided to prevent degradation. For heat-sensitive applications, encapsulation or spray-coating techniques provide additional protection.

Q: How does this ingredient interact with other anti-aging actives?

A: The compound exhibits synergistic effects when combined with NAD+ boosters, mitochondrial antioxidants, and telomerase activators. No antagonistic interactions have been reported with common nutraceutical ingredients. Stability testing in specific formulation matrices is recommended during product development.

Q: What payment and ordering methods do you accept?

A: We process 100% T/T bank transfers, Alibaba International Trade Assurance orders for secure online transactions, and WeChat/Alipay payments for mainland China customers. MOQ and pricing tiers vary based on order volume and customization requirements.

Q: Are samples available for formulation testing?

A: Standard specification samples (10-50g) ship within 2-3 business days after request approval. Sample costs are credited toward initial bulk orders. Custom specification samples require lead time coordination based on production scheduling.

Partner With Us for Reliable Raw Material Supply

Ready to source premium-quality raw materials for your next innovation? Contact our global supply team at enquiry@lenutra.com to discuss your Piperlongumine Powder project requirements and receive detailed quotations.