Nattokinase Powder

Premium Nattokinase Powder – Standardized Fibrinolytic Enzyme for Cardiovascular Health Solutions

Xi'an Le-Nutra Ingredients Inc. is a manufacturer of high-quality Nattokinase Powder from non-GMO fermented soybeans and controlled biofermentation method. Our product is standardised to 2000 FU/g enzyme activity from Bacillus subtilis natto fermentation and is made in our 60,000㎡ GMP-certified facility with annual production capacity of 3,000 tonnes. With 14+ years of experience in natural ingredient extraction, we ensure tight quality control, thorough elimination of interfering substances and consistent batch to batch stability. Our factory-direct supply chain supplies reliable cardiovascular enzyme solutions to nutraceutical producers, supplement brands, and functional food developers throughout the world with full documentation support including COA, TDS, MSDS, and regulatory certifications.

What Is Nattokinase Powder?

The product is a fibrinolytic serine protease enzyme prepared and purified from natto, a traditional Japanese fermented soybean snack generated by Bacillus subtilis var. natto. This is a subtilisin family active enzyme with a molecular weight of approximately 27.7 kDa and comprised of 275 amino acid residues.

Unlike synthetic anticoagulants, the natural enzyme directly hydrolyses fibrin and activates endogenous production of tissue plasminogen activator (t-PA). It overcomes key industry challenges: measurement of enzymatic activity in Fibrin Units (FU), removal of Vitamin K2 to avoid interference with anticoagulant medications, and removal of the signature pungent natto smell to improve consumer acceptance in dietary supplements.

Our product is a free flowing fine powder of light yellow to light beige with great water solubility and it's appropriate for a variety of formulation applications in tablets, capsules, functional beverages and wellness products for circulatory health.

Standardized Specifications & Quality Parameters

Core Health Benefits & Functional Applications

Your customers demand natural cardiovascular support ingredients with proven efficacy. Our Nattokinase Powder delivers six key functional advantages that set your finished products apart in competitive markets.

Thrombus Lysis & Fibrinolysis

The enzyme breaks down fibrin networks in blood clots directly, providing a natural alternative to prescription thrombolytics. This system helps to re-establish healthy blood flow in impaired circulatory systems.

Blood Viscosity Lowering

It helps to keep the blood fluid by breaking down excess fibrinogen and boosting plasmin activity. lower viscosity leads to less workload on the heart and better oxygen supply to tissues.

Keeping the Cardiovascular System Healthy

Regular supplementation enhances circulatory system flexibility and endothelial function. This enzyme helps avoid aberrant clot formation and maintain normal haemostatic equilibrium.

Improving Peripheral Circulation

Increased blood flow to the extremities reduces symptoms of numbness, tingling, and chilly feelings in the hands and feet. This advantage is especially valued in formulations aimed at the ageing population.

Brain Circulation Assist

Better blood flow to the tissues of the brain decreases dizziness and improves mental functioning. The enzyme’s ability to decrease microthrombi production helps to improve cerebral oxygen delivery.

Modulation of Systemic Inflammatory Response

Recent studies indicate that nattokinase might have an effect on inflammatory indicators linked to vascular stress, lending an anti-inflammatory aspect to its cardiovascular advantages.

Manufacturing Excellence & Quality Assurance

We adhere to pharmaceutical-grade manufacturing standards throughout the whole manufacturing process. We operate a 60000㎡ facility with 6 multipurpose production lines under strictly compliance GMP, ISO, and FDA systems.

The fermentation process involves carefully selected strains of Bacillus subtilis natto, cultivated under controlled temperature, pH and oxygen conditions. Multi-stage purification by membrane filtering, chromatographic separation and spray-drying is performed after fermentation to yield a constant activity of 2000 FU/g.

Our skilled QC team checks at every step of the production process. Sophisticated analytical tools check enzyme activity, protein content, residual solvents, heavy metals, microbial load and pesticide residues. Every lot is supplied with full traceability paperwork which includes COA, TDS, MSDS and third party lab verification on request.

Temperature management throughout processing is important. We don't go above 50°C for the extraction and drying steps so the enzymes stay intact. Stability testing of the final product is done to demonstrate that the activity is preserved throughout shelf life of 24 months when stored under the recommended conditions.

Formulation Guidelines & Technical Support

Enzyme Activity Protection

Store opened containers sealed in cool, low-temp conditions. - Do not mix with adjuvants at temperatures above 40°C in the tableting or encapsulating processes; at higher temperatures the enzymes lose their activity irreversibly.

Compatibility Recommendations

Do not mix with high temperature raw materials in manufacturing process. Finishing health goods in combination with mild botanical extracts such as ginkgo biloba or hawthorn berry, protects their complete fibrinolytic activity.

Delivery System Optimization

The best bioavailability is achieved with enteric-coated capsules . They prevent the breakdown of the compound in the stomach acid . Optimal stability was observed at pH 6.0-10.0 with fast inactivation below pH 5.0.

Dosage Considerations

Clinical investigations have shown a maintenance dose of 2,000 FU daily for general circulatory support. 4,000-6,000 FU per day, as always confirmed by JHFA-certified laboratory testing, may be of benefit to high risk cardiovascular profiles.

Our R&D team offers complete technical consultation for your individual formulation needs including stability studies, dissolution testing and regulatory compliance support for worldwide markets.​​​​​​​

Global Supply Chain & Customization Services

We are a direct factory supplier thus there are no middlemen and you can get low prices and guarantyd consistency in the goods. Our reliable supply network consists of certified organic farms and strategic safety stock to ensure uninterrupted availability with over 30 days of inventory.

OEM/ODM Capability

We provide total customisation – formula creation, activity specification change from 2,000 to 20,000 FU/g, private labelling and package design. We have a variable MOQ to suit trial orders or mass commercial production.

Delivery and Logistics

We offer EXW, FOB, CFR, CIF, DAP and DDP terms with reliable international shipping via sea freight, air cargo and express courier services. We help keep your production schedules on track with 98% on-time delivery in North America, Europe, Southeast Asia and emerging markets.

Flexible Payment Options

We accept 100% T/T, Alibaba Trade Assurance orders and western union for different business relationships and transaction preferences.

Delivery Time

Standard specs in stock ship within 3-5 business days. Custom orders (bulk or high-purity) take 10-12 days for manufacture and quality verification.

Packaging & Storage Requirements

Standard Packaging is fibre drums of 25 kg with double layer food grade polyethylene bags to avoid moisture and contamination. Private label specifications with custom packaging possibilities.

Store in cool, dry, dark place away from sources of bright light, heat and moisture. Enzyme activity is best retained when stored at temperatures below 25°C. Product stored properly will sustain full activity for 24 months from date of manufacture.

FAQ

Q: What is the difference between Nattokinase and prescription blood thinners?

A: Nattokinase does not interfere with clotting factors like medications, but actually degrades existing fibrin and increases the body's own natural ability to dissolve clots, generally with less negative effects.

Q: Why is the 'FU' unit better than milligrams?

A: FU is a unit of biological activity (potency). Milligrams simply measure weight. 100mg of weak nattokinase may have 0 FU.

Q: Can nattokinase survive stomach acid?

A: It is relatively stable, however for best efficacy enteric-coated capsules or high-activity concentrates are recommended to enable bypass of the low pH environment of the stomach.

Q: Is it safe for gout patients?

A: Yes, providing the nattokinase is properly purified and the purine-rich soy residue produced during fermentation has been eliminated during processing.

Q: What is the recommended daily intake?

A: Clinical research supports 2,000 FU daily for maintenance and up to 4,000-6,000 FU for those with high-risk cardiovascular profiles, always confirmed with a JHFA-certified lab assay.

Partner With Le-Nutra for Cardiovascular Innovation

Contact our global customer support team at enquiry@lenutra.com to discuss your Nattokinase Powder requirements, request samples, or explore customization options tailored to your market needs.