Palmitoylethanolamide Powder

Palmitoylethanolamide Powder – Premium Grade Anti-Inflammatory Ingredient for Nutraceutical and Cosmetic Applications

Xi'an Le-Nutra Ingredients Inc.manufactures pharmaceutical quality Palmitoylethanolamide Powder with purity ≥98% and ≥99% using sophisticated crystallisation and purification processes. We supply this world-recognized anti-inflammatory active ingredient with comprehensive compliance paperwork (COA, TDS, ISO, Halal, Kosher) backed by our 60,000㎡ GMP-certified production facility and 3,000-ton annual capacity. Our solution addresses important formulation issues in the nutritional supplement and topical skincare industries delivering standardised, micronised particles for encapsulation in capsules, compression into tablets and dispersion in creams. We have over 14 years of experience processing bioactive ingredients, guaranteeing batch to batch quality, low heavy metal residues (≤10 ppm) and low moisture content (≤0.5%) in compliance with international food-grade and cosmetic-grade standards.

What Is Palmitoylethanolamide Powder?

Palmitoylethanolamide (PEA) is an endogenous fatty acid amide, endogenously produced in the body in response to inflammation and cellular stress . It is a white to off-white crystalline powder like substance with melting point of 96-99℃.

Our N-(2-Hydroxyethyl)hexadecanamide (CAS: 544-31-0) is a stable free flowing solid state during the manufacturing process. This avoids the risk of oxidation of lipid-based raw materials and assures a 24-month shelf life under optimal storage conditions.

The powder form offers accurate dosage in tablets, capsules and topical preparations. It is stable during the manufacturing process and is therefore suitable for oral nutritional supplements and dermatological uses.

Technical Specifications and Quality Standards

Triple-Action Mechanism for Health Applications

Anti-Inflammatory & Pain Relief Function

PEA activates peroxisome proliferator-activated receptor-alpha ( PPAR-α ) that down-regulates pro-inflammatory cytokine expression. Clinical trials have shown that it can effectively manage chronic pain disorders without the GI adverse effects of standard NSAIDs.

Nerve Repair & Sooth Properties

This element contributes to maintaining brain health by influencing glial cell activity and enhancing myelin sheath integrity. It has special promise for formulations aimed at neuropathic pain and nervous system regeneration.

Soothing & Anti Itching Benefits

In topical use, PEA prevents degranulation of mast cells and release of histamine This makes it useful for skincare products that deal with sensitive skin disorders, reducing irritation and encouraging the restoration of barrier function.

Why Choose Our Palmitoylethanolamide Powder?

End-to-End Quality Assurance

Each production batch is rigorously tested for purity by HPLC, screened for microbes and analysed for heavy metals. With every shipment we give complete documentation including Certificates of Analysis, Technical Data Sheets and third party lab results.

We are a GMP level manufacturing facility with stringent environmental controls. Each step, from raw material check to final packaging in double layer food grade polyethylene bags inside 25 kg fibre drums, is carried out according to approved methods.

Globally Compliant Multi-Market Ingredient

The substance is permitted for usage legally in food supplements and cosmetics across North America, Europe and the Asia Pacific. It doesn't require specific permission for commercial formulation, unlike restricted pharmaceutical chemicals.

Palmitoylethanolamide Powder is a multi-functional ingredient that allows formulators to target two two hundred billion dollar sectors at the same time: Oral health supplements and topical skincare. One well-documented ingredient.

Customised Service Support

Our R&D team works with clients to make changes to the specifications, such optimising the particle size for better dissolving rates or specific mesh sizes for encapsulating equipment. We have private label and custom package configurations.

Minimum order quantities are adjustable to allow pilot production and market testing phases. Technical consultation comprises stability testing methodologies, recommended excipient compatibility and dosage form formulation.

Application Guidelines for Formulation Development

Formulations for Dietary Supplements

Typical doses are 300-1200mg daily as vegetarian capsules, pills or powder sachets. The constituent is highly stable in the presence of conventional flowing agents and disintegrants.

Flowability of such material in automated capsule-filling equipment is improved by pre-blending with silicon dioxide or microcrystalline cellulose. Compression properties allow direct tablet production with suitable binders.

Integration of Skincare

Anti-inflammatory effects are provided by concentrations of 0.1-2.0% in cream and lotion bases. Powder is pre-mixed with emulsifiers and then uniformly dispersed in oil phases before the aqueous phase addition.

For maximum skin penetration use with penetration enhancers and/or liposomal delivery systems. Cold process production is advantageous for heat-sensitive formulations to retain bioactivity.

Packaging and Global Delivery

Our usual packing is in 25 kg fibre drums with double layer food grade polyethylene bag liners which provide moisture resistant and contamination free protection during transportation. Alternative packing options can be provided on request.

We provide all kinds of delivery terms such as EXW, FOB, CFR, CIF, DAP, DDP for all different international trade needs. Payment alternatives include T/T, Western Union, PayPal, and Alibaba Trade Assurance for safe transactions.

We have created logistical agreements in North America, Europe and Southeast Asia to achieve 98% on time delivery rates. Our expert export staff takes care of all the documents, assuring easy customs clearance at your market.

FAQ

Q: How does the product's solubility vary across different solvents?

A: PEA is not very soluble in water but is readily soluble in ethanol, DMSO and medium chain triglyceride oils. Micronising to 200-mesh particle size for oral supplements improves bioavailability. Lipid-based delivery systems or self-emulsifying pharmaceutical delivery systems (SEDDS) considerably increase absorption rates.

Q: How do you assure consistency between batches in the case of medicinal applications?

A: We employ validated analytical procedures such as HPLC fingerprinting, melting point checking and particle size distribution analysis. Each batch is compared with the reference standards. We have a quality control team that maintains statistical process control charts to detect any drift in essential quality attributes prior to release.

Q: Is it okay to use this substance with other anti-inflammatory ingredients?

A: Yes. PEA has synergistic effects when combined with curcuminoids, boswellia extracts or omega-3 fatty acids. Stability investigations demonstrate no harmful interactions during 24-month accelerated shelf life testing. We offer compatibility data to help in the formulation of multi-ingredient formulas.

Q: What documents do you supply for global regulatory submissions?

A: We have total regulatory assistance packages comprising Certificates of Analysis, Allergen Declarations, Non-GMO statements, Heavy Metal test reports, Microbial test findings, Halal and Kosher certifications, and GMP compliance letters. We supply REACH pre-registration papers to EU customers. Plant sourced. BSE/TSE certificates available.

Q: What is your lead time and MOQ?

A: Standard runs are completed in 15-20 working days from confirmation of order. We have safety stocks of common standards (98% and 99% purity) for more than 30 days for urgent needs. Minimum order quantity is 25 kg (one drum) with flexible options for trial orders. Your cargo is shipped by sea, air cargo or express via global logistics partners to meet your schedule needs.

Partner with a Trusted Ingredient Supplier

Ready to incorporate pharmaceutical-grade Palmitoylethanolamide Powder into your next formulation? Contact our technical team at enquiry@lenutra.com for samples, detailed specifications, or custom development consultation.