7-Dehydrocholesterol

7-Dehydrocholesterol Powder – Premium Provitamin D3 Intermediate for Pharmaceutical and Cosmetic Applications

Xi'an Le-Nutra Ingredients Inc. is specialised in the production of pharmaceutical and cosmetic grade 7-Dehydrocholesterol powder with purity ≥95.0% and ≥98.0%. More than 14 years experience in natural ingredients manufacture. We have a 60,000㎡ production plant, with an annual capacity of 3,000 tonnes, assuring reliable supply and consistent quality for global vitamin D3 synthesis and sophisticated skincare formulations. Each batch is rigorously tested for HPLC purity, melting point and heavy metals screening. Light-proof sealed production throughout the process prevents oxidation and assures product stability during its 24-month shelf life.

What Is 7-Dehydrocholesterol and Why Your Formulation Needs It?

The result is a zoosterol and the immediate metabolic precursor of Cholecalciferol (Vitamin D3) also known as Provitamin D3 or 7-DHC. This substance is crystalline and is naturally found in the epidermal layers of the skin. UVB radiation activates this compound to photochemically convert it into active Vitamin D3.

In pharmaceutical manufacturing, the product meets the important need for high purity precursors in Vitamin D3 production lines. It provides a lipophilic active ingredient for cosmetic makers that strengthens the skin barrier and mimics natural lipid profiles.

This substance serves two fast growing market areas. The supplement sector is experiencing increased demand driven by growing consumer awareness of bone health and immune support; the trend for biomimetic skincare products is creating potential in cosmetics.

Technical Specifications and Quality Parameters

Core Functional Advantages for Your Product Development

Conversion of Provitamin D3

The product is a substrate for photochemical production of vitamin D3. It is converted into cholecalciferol during manufacture by exposure to regulated UVB irradiation with optimised yields of 30-60% per processing cycle. This makes it a must-have for pharmaceutical companies that provide vitamin supplements for bone health, immunological function and calcium metabolism.

Calcium Absorption Enhancement

This molecule acts as a precursor of active Vitamin D3 and promotes metabolic pathways of calcium and phosphorus balance. Properly irradiated product derivatives can be formulated into supplement formulations that end customers can use to address deficiency related illnesses such as osteoporosis, rickets.

Strengthening Skin's Barrier

In cosmetic applications, the substance functions as a biomimetic lipid component and is incorporated into the stratum corneum lipid layers. Its structural resemblance to endogenous skin sterols allows it to improve barrier function, minimise transepidermal water loss and provide conditioning effects in luxury skincare products for the treatment of photo-damage and barrier restoration.

Manufacturing Excellence and Quality Assurance

We have a 60,000㎡ GMP production base with six multipurpose production lines equipped with modern extraction and purification equipment. Every batch passes through three levels of strict quality control procedures.

The raw material check assures the traceability of the source and NF grade quality of the lanolin first. Second, in-process monitoring such as HPLC purity analysis, melting point testing (148-152°C) and heavy metal screening to meet pharmaceutical and cosmetic safety standards . Third, microbiological safety is assessed by completed product testing with total plate counts <100 CFU/g and no harmful microorganisms.

Our production environment is sealed and light-proof with nitrogen protection to prevent photolysis and oxidative deterioration. With this thorough process stability control, you can get 7-Dehydrocholesterol powder which is potent during storage and shipping.

Flexible Customization Services for Your Business Needs

Specification Customization

We have two grades of standard pharmaceutical grade (≥98.0% purity) and cosmetic grade (≥95.0% purity). Your technical team can partner with our R&D professionals to tailor purity levels, particle size distribution or residual solvent restrictions to suit your downstream processing requirements.

Packaging Solutions

Normal packaging is 25 kg fibre drums with double layer food grade polyethylene bags and nitrogen flushing. For more sensitive applications that require longer stability, we provide specialised small batch packaging with improved light protection and desiccant included.

Technical Support During Development

Our expert chemists may provide guidance on photochemical conversion processes, solubility enhancement strategies for aqueous formulations and regulatory paperwork help. We help you negotiate TSE/BSE compliance standards and coordinate third-party testing.

Flexible MOQ Available

Many suppliers require multi-ton purchases, however we support smaller orders for R&D projects or first market tests. This provides emerging companies and research institutions with access to pharmaceutical-grade ingredients without undue inventory risk.

Global Supply Chain and Delivery Capabilities

We maintain a strategic safety stock of more than 30 days of average order volume, enabling us to quickly fill orders for time-sensitive projects. We have a logistics network that can meet your procurement needs with EXW, FOB, CFR, CIF, DAP, DDP and other conditions of delivery.

We have a 98% on-time delivery rate, and we serve customers in North America, Europe and Southeast Asia through reliable sea freight, air cargo and fast courier solutions. Every shipment is accompanied by complete documentation: Certificate of Analysis, Technical Data Sheet, Allergen Statement, Non-GMO Declaration and Halal/Kosher certifications upon request.

Our quality management system conforms with the requirements of ISO and GMP standards and guarantees full batch traceability, enabling us to respond quickly to any inquiry or regulatory audit need.

FAQ

Q: What is the origin of your product?

A: We normally obtain our product by saponification and separation of NF grade sheep lanolin. There are semi-synthetic ways from cholesterol for certain high purity pharmaceutical applications with non-TSE/BSE risk compliance.

Q: How should the product be stored for potency?

A: Store in firmly sealed containers under nitrogen protection at temperatures below -15°C to -20°C, due to its sensitivity to oxidation and light. It degrades rapidly upon exposure to room temperature, air or light.

Q: Can I take this powder straight as Vitamin D3?

A: No. The product is the precursor provitamin. It has no vitamin D activity until photochemical conversion by UV irradiation has taken place. It is a substrate, not the end-active vitamin.

Q: What is the average shelf life?

A: A good product should be stable for 24 months under adequate cold, dark and anaerobic conditions. If packages have been opened or held beyond recommended durations, we propose retesting by HPLC.

Q: Is the material vegan?

A: Commercial lanolin is made from sheep wool and is not vegan. However, for specialised vegan certification applications, there are yeast-derived or plant-sterol synthetic methods, although these are at a premium due to limited availability.

Contact Us for Samples and Technical Consultation

Ready to enhance your vitamin D3 production efficiency with 7-Dehydrocholesterol or develop advanced skincare formulations? Contact us at enquiry@lenutra.com to discuss your specific requirements and receive a detailed quotation.