Protocatechualdehyde

Protocatechualdehyde 99% Pure Powder – Premium Pharmaceutical Intermediate for Cardiovascular and Antioxidant Applications

Xi'an Le-Nutra Ingredients Inc. offers high purity Protocatechualdehyde (CAS 139-85-5) with ≥99% specification from our 60,000㎡ GMP compliant plant and annual capacity of 3,000 tonnes. This pale yellow to off white crystalline powder is a key pharmacological intermediary and bioactive chemical that occurs naturally in medicinal plants including Salvia miltiorrhiza and Coptis chinensis. Our product has a chemical formula of C7H6O3 and molecular weight of 138.12 4. It has excellent antioxidant efficiency, antiplatelet aggregation characteristics and neuroprotective advantages. Each batch is subjected to full testing for HPLC-DAD purity, heavy metals (ICP-MS) and microbiological content to fulfil international pharmacopoeia and to assure a steady supply for research of cardiovascular API, TCM quality control and synthesis of organic compounds.

What Makes Protocatechualdehyde Essential for Modern Pharmaceutical Development?

The substance, also known as 3,4-dihydroxybenzaldehyde, tackles major industry issues in pharmaceutical manufacture and natural product research. The twin hydroxyl groups on its benzene ring structure give greater radical scavenging ability, with IC50 values greatly surpassing Vitamin E in typical DPPH experiments.

This phenolic aldehyde passes the blood-brain barrier effectively, making it valuable for neuroprotective compositions. Its multi-pathway anti-inflammatory actions provide advantages over synthetic antioxidants in therapeutic applications.

Traditional Chinese medicine makers rely on this chemical as a reference standard for quality control and fingerprinting investigations. The compound's stability throughout industrial heating operations ensures consistent results in complex synthesis techniques.

Technical Specifications and Quality Parameters

Our quality control system includes HPLC-DAD for purity verification and ICP-MS for heavy metal screening. Each batch is fully documented with COA, TDS, MSDS and chromatographic data .

Core Pharmacological Advantages

Benefits to Heart Health

Clinical studies have shown that it has considerable effects of anti-platelet aggregation and anti-myocardial ischaemia . These features contribute to the development of APIs for treatment of complex haemodynamic disorders and microcirculation improvement.

Improved Antioxidant Activity

The catechol structure is an analogue of DOPA with higher free radical scavenging activity. It stabilises compositions against oxidation generated by UV light in high-end dermatological products.

Mechanisms Of Neuro-protection

Its capacity to cross the brain barriers allows protective effects in neurological research. Its anti-inflammatory mechanisms further add to its benefit to the management of disorders associated to oxidative stress.

Standardisation of TCM

It is a chemical marker for traditional medicinal herbs, giving acceptable reference standards for quality assurance methods in the preparation of botanical extracts.

Industrial Applications Across Three High-Value Sectors

Pharmaceutical Intermediate Synthesis

This Protocatechualdehyde molecule can be used to make compounds similar to adrenaline, antibiotics and antiviral drugs. The material presents a high thermal stability retaining the structural integrity for multi-step synthesis techniques.

API Research in Cardiovascular

It is of known biological action and is useful to researchers designing treatments for cardiac ischaemia and platelet aggregation disorders. The chemical is a research tool and a possible active ingredient.

Flavour and Perfume Chemistry

It is used as a vanillin precursor in flavour production and has melanin-inhibiting activity in dermatological formulations. The solubility profile makes it easy to include into complex formulation matrices.

Comprehensive Customization and Supply Solutions

Flexible Packaging Choices

For R&D purposes we offer 1kg, 5kg and 10kg aluminium foil bags. For commercial scale manufacturing we offer 25kg fibre drums with double layer food grade polyethylene liners. We also provide custom repackaging and private label services to meet your specific branding demands.

Multiple Terms of Delivery

Select EXW, FOB, CFR, CIF, DAP or DDP terms according to your logistics requirements. Our international supply network provides reliable transportation throughout North America, Europe and Southeast Asia.

OEM/ODM

Our R&D staff can build formulas, alter specifications, and optimise processes. Whether you require customised purity levels or specific particle size distributions, we provide tailored solutions.

Lead Times and Safety Stock

We have more than 30 days of inventory stored under controlled conditions (2-8°C, protected from light) and deliver 98% on time for standard and rush orders.

Quality Assurance and Regulatory Compliance

With over 14 years experience in the production of natural ingredients, we guarantee that every lot meets stringent quality standards. GMP-certified facilities and ISO-compliant procedures oversee the entire manufacturing process.

Strictly following international standards: Heavy metal limits are Lead <2ppm Arsenic <1ppm Cadmium <1ppm Gas Chromatography residual solvent screening as per USP 467> recommendations.

Stability testing involves monitoring absorbance patterns to identify quinone degradation products. To avoid oxidative polymerisation during storage, moisture content is kept below 0.5%.

Third-party testing support and full batch traceability paperwork are included with every shipments. We have a competent QC laboratory to conduct microbiological assays to validate total plate counts and yeast/mold levels suitable for nutraceutical and cosmetic use.

Storage and Handling Best Practices

Proper storage prevents degradation of the catechol structure, which remains sensitive to photo-oxidation. Maintain airtight containers in cool, dry, well-ventilated areas at 2-8°C temperatures.

Protect containers from direct light exposure throughout the 24-month shelf life. Nitrogen-purged environments further extend stability for long-term research projects.

Avoid alkaline formulation environments where phenolic groups deprotonate and become susceptible to rapid oxidation. The melting point range of 150-157°C guides thermal processing parameters.

High-purity synthetic versions offer superior batch-to-batch consistency compared to natural extracts, though both forms remain chemically identical. Your application requirements determine the optimal sourcing strategy.

Packaging and Storage Specifications

Standard pharmaceutical-grade packaging utilizes 25kg fiber drums with dual-layer food-grade polyethylene protection. Research quantities ship in sealed aluminum foil bags preventing moisture ingress and light exposure.

All containers undergo leak testing before shipment. Labels include batch numbers, manufacturing dates, and storage instructions complying with GHS classification requirements.

Temperature-controlled logistics maintain cold chain integrity during international transit. We recommend immediate transfer to refrigerated storage upon receipt to preserve optimal stability throughout the shelf life.

Partner With a Trusted Manufacturer

Xi'an Le-Nutra Ingredients Inc. combines direct factory advantages with advanced production capabilities. Our 6 multifunctional production lines handle diverse plant materials and synthesis protocols efficiently.

The professional R&D team collaborates with your technical staff throughout project development. From initial sample evaluation through commercial-scale production, we provide responsive multilingual support.

Long-term supply agreements benefit from volume-based pricing and priority production scheduling. Our reliable raw material network and certified organic farm partnerships ensure consistent quality regardless of order size.

Global customers across pharmaceutical, cosmetic, and food industries trust our compliance management systems and full-cycle quality assurance protocols.

FAQ

Q: How does synthetic product compare to naturally extracted versions?

A: While chemically identical, synthetic production delivers better consistency for pharmaceutical synthesis. Natural extracts may contain botanical co-factors suitable for certain TCM applications.

Q: What analytical methods verify purity?

A: We employ HPLC-DAD to confirm ≥99% purity and identify related substances. Each batch includes detailed chromatographic data demonstrating compliance with ChP and USP reference standards.

Q: Can this compound withstand formulation heating processes?

A: Yes, the melting point of 150-157°C and thermal stability allow it to maintain integrity during controlled heating. However, avoid prolonged exposure to temperatures exceeding processing requirements.

Q: Is it compatible with aqueous formulations?

A: The compound shows excellent solubility in ethanol and ether, with moderate solubility in hot water. Cold water applications require solubilization strategies or co-solvents.

Q: What documentation supports regulatory submissions?

A: Standard packages include Certificate of Analysis, Technical Data Sheet, Material Safety Data Sheet, and HPLC chromatograms. Additional third-party testing reports are available upon request.

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Contact Us for Technical Consultation and Samples

Ready to integrate high-purity Protocatechualdehyde into your formulations? Request samples pricing information by contacting us at enquiry@lenutra.com. Experience the difference that 14+ years of natural ingredient expertise delivers.